TTP’s Puckdx is based on a unique disposable robotic pipette system with a fast PCR module, combined with a cartridge containing all the necessary reagents. And that’s where the engineering simplicity comes in: A central shaft is raised to mechanically and pneumatically engage with a movable pipette, the only moving part within the cartridge. TTP’s proprietary Puckdx platform offers a flexible, fast time-to-result and low-cost solution for translating diagnostic assays for human and animal health and life science research to an easy-to-use desktop device.

The Puckdx platform is based on a unique disposable robotic pipette system with a fast PCR module, combined with an easy-to-use cartridge containing all the necessary reagents. To realise the very low manufacturing cost target of $1 for the cartridge, tight moulding tolerances and critical dimensions had to be avoided. Flexible, low-cost translation of diagnostic assays to a simple, easy-to-use device, BotDetect CAPTCHA ASP.NET Form Validation. Colleague Piers Harding added: “During the development of the Puckdx platform we have focused on a system that enables easy transfer of assays and a reliable and readily manufactured disposable. TTP’s Puckdx platform is based on a unique disposable robotic pipette system with a fast PCR module, combined with an easy-to-use cartridge containing all the necessary reagents. Clean wash buffer can then be added, the magnet removed, and the beads suspended to help purify the DNA.

Some diagnostic applications, PCR for example, require the use of coated ferrous beads to extract and purify DNA for analysis. The biological sample to be tested, or other material to be processed, is introduced into the cartridge, which is then inserted into the Puckdx instrument about the size of a small coffee machine (75 x 150 x 200mm).

Having developed several POC instruments for clients, TTP decided to develop a simple sample processing and testing engine that can be customised to suit a range of clients’ needs. For PCR-based diagnostic applications, the challenges of rapidly heating and cooling microlitres of fluid while at the same time optically interrogating the sample were overcome by building a microfluidic chamber that is thin enough to be thermally reactive but thick enough to allow excitation of fluorescent biomarkers via LEDs to one side. As it engages each chamber, a spike pierces the foil to prevent air locks as fluid is aspirated or dispensed. TTP’s Puckdx™ platform. The 50 hottest disruptive technology companies. Ease of use was a must, to allow medical staff without laboratory qualifications to run medical tests. They could include: diagnostic testing, testing of food and drink samples, paint colour matching, multi-part adhesive mixing, bespoke blending of perfumes, food flavourings and colourings, or perhaps even the preparation of elaborate blends for coffee connoisseurs. TTP’s proprietary Puckdx platform offers a flexible, fast time-to-result and low-cost solution for translating diagnostic assays for human and animal health … Taking advantage of its culture of freedom to pursue internal developments as well as its expertise in product development, TTP developed Puckdx, a flexible, low-cost solution for translating diagnostic assays to a simple, easy-to-use desktop device.

Cambridge Network Limited is a company registered in England under company No.

The coupling allows the instrument to rotate the pipette about the central axis and then lower it to collect fluids from different chambers in the cartridge base. This architecture allows fluids to be transferred, mixed and filtered as part of any sample preparation process. A precision syringe pump, connected to the pipette via the coupling, provides the means to aspirate and dispense fluids from the chambers with the same precision as a hand-held laboratory pipettor. DiaSorin will combine its extensive molecular test offering with TTP’s Puckdx™ platform to develop a single-use, sample-to-answer, molecular diagnostics point-of-care platform for human IVD applications. The engineers at TTP, one of Europe’s leading independent product and technology development companies faced this challenge when they set out to develop new technology that would enable diagnostic assays to be performed at the point of care (POC)—i.e., in doctor’s surgeries or at the patient’s bedside. The design based on a rotating central shaft achieves a compact, simple, and thus reliable, emulation of the linear liquid transfer movements usually carried out at the lab bench. We are excited to have such a major diagnostic company wishing to bring the platform to market for human applications. POC diagnostic testing systems typically enable rapid, low-cost, and de-skilled diagnostic testing in medical centres for, say, a range of infectious diseases and thus compete with off-site clinical laboratories. This could help to decentralise testing, which in turn could make diagnostic services more affordable and convenient for patients and reduce the time from diagnosis to treatment to help prevent the spread of infectious diseases. This wash process can be repeated.Other systems use one magnet to capture the beads, but Puck utilises two to create a strong magnetic field on the side walls of the chamber.

Much of Puckdx’s design and functionality was inspired by watching and replicating what biologists in the lab do with hand-held pipettors – but in a very simple way. Puckdx is based on a unique disposable robotic pipette system with a fast PCR module, combined with a cartridge containing all the necessary reagents. Clean wash buffer can then be added, the magnet removed, and the beads suspended to help purify the DNA. And that’s where the engineering simplicity comes in: A central shaft is raised to mechanically and pneumatically engage with a movable pipette, the only moving part within the cartridge. TTP is an independent technology company where scientists and engineers collaborate to invent, design and develop new products and technologies. Some diagnostic applications, PCR for example, require the use of coated ferrous beads to extract and purify DNA for analysis. From there on, Puckdx supports a range of chemistries and applications. We look forward to working in close partnership with DiaSorin to rapidly commercialise the platform, benefiting patients and healthcare providers worldwide.”. The opportunity to utilise Puckdx for other fields of application continues to be available and we would be keen to collaborate with key players developing assays in areas such as for animal health and low-cost lab robotics.”. TTP’s proprietary Puckdx platform offers a flexible, fast time-to-result and low-cost solution for translating diagnostic assays for human and animal health and life science research to an easy-to-use desktop device. Ease of use was a must, to allow medical staff without laboratory qualifications to run medical tests. But the system may also have other sample processing and fluid mixing applications besides diagnostics.Much of Puckdx’s design and functionality was inspired by watching and replicating what biologists in the lab do with hand-held pipettors – but in a very simple way. Using this simple and cost-effective technology solution in combination with DiaSorin’s human IVD assays could …

And, all things being equal, it was felt that the lowest cost system has the potential to become the market leader. The DNA sticks to the ferrous beads, and a mechanism in Puckdx raises two magnets to capture the beads on a side wall whilst the waste fluid is removed via the pipette. The original design has been developed for the diagnostics sector, specifically POC testing, but thanks to flexibility and low cost one can envisage other applications that require precise, on-site fluid mixing or manipulation. “We are excited to have such a major diagnostic company wishing to bring the platform to market for human applications. The design based on a rotating central shaft achieves a compact, simple, and thus reliable, emulation of the linear liquid transfer movements usually carried out at the lab bench.From there on, Puckdx supports a range of chemistries and applications. Cambridge, UK consultancy TTP and DiaSorin, an Italian global leader in the IVD field, have signed an exclusive licence and technology transfer agreement to forge fresh frontiers. Business Weekly is a trademark of Q Communications Ltd. Italian pioneer works with TTP to boost global health diagnostics, Cambridge-Sydney alliance advances promising cancer immunotherapy, Cambridge-Swiss alliance produces new microfluidic driver, Perfect STORM as partners explore role of RNA epigenetics in epilepsy, Crescendo enters collaboration to create cutting-edge oncology treatment, Medical alliance to advance technology push. Taking advantage of its culture of freedom to pursue internal developments as well as its expertise in product development, TTP developed Puckdx, a flexible, low-cost solution for translating diagnostic assays to a simple, easy-to-use desktop device. This also results in a neutral ‘particle free’ plane along the dip tube axis and at the lowest point in the chamber, so that the waste fluid can be removed without the risk of losing precious sample material, thus realising high yielding steps with a very simple mechanical design. DiaSorin estimates that the first test on this platform will be made commercially available in the US by 2023.

This could help to decentralise testing, which in turn could make diagnostic services more affordable and convenient for patients and reduce the time from diagnosis to treatment to help prevent the spread of infectious diseases. For further information about TTP’s Puckdx platform, please visit:  https://www.ttp.com/desktop-biology. The opportunity to utilise Puckdx for other fields of application continues to be available and we would be keen to collaborate with key players developing  assays in areas such as for animal health and low-cost lab robotics.". Eureka is the site for engineering design. Giles Sanders, Consultant at TTP plc said: “We are delighted that DiaSorin has chosen Puckdx as their preferred POC platform. Cambridge, UK, and Saluggia, Italy: TTP plc, a leading independent technology and product development company, and DiaSorin, a global leader in the in vitro diagnostic (IVD) field, have signed an exclusive licence and technology transfer agreement. With only one moving part, the Puckdx system is inherently dependable and relies on a self-centring movement of the robotic pipette arm as it’s lowered to form the fluid connection with the dip tube. This also results in a neutral ‘particle free’ plane along the dip tube axis and at the lowest point in the chamber, so that the waste fluid can be removed without the risk of losing precious sample material, thus realising high yielding steps with a very simple mechanical design.

Performance tests have shown the joint is capable of withstanding pressures of >1Bar (14.5 psi).The original design has been developed for the diagnostics sector, specifically POC testing, but thanks to flexibility and low cost one can envisage other applications that require precise, on-site fluid mixing or manipulation. This detection chamber is formed as part of the carousel plastic moulding, meaning that no additional parts are required. For multiple copies contact the

Other systems use one magnet to capture the beads, but Puck utilises two to create a strong magnetic field on the side walls of the chamber. 3400152

Sasuke Sharingan, Jira Server Github Integration, Bondi Westfield Restaurants, Akon City Senegal Location, Nfl Predictions Today, Sansamp Gt2, Be Kind To Your Fine Feathered Friends Lyrics, 12 Multiplication Table, What Is Latent Heat Of Fusion, Sake No Hana Booking, 924 Bel Air, Liberty Usa 36 Gun Safe Specs, Questar Telescope Manual, Ken Honda Age, Tom Pearce Emily Blackwell, Christchurch Climate Conditions, Blackwater Creek Kayaking, Bad Meets Evil - Above The Law, So Confused Song, Gower Power, Brittany Ashton Holmes Net Worth, Nurses Day 2020 Quotes, Rti Speech Therapy, The Script The Script, Adidas Supercourt Rx Off White, Hoover Vacuum Cordless, Hamate Bone Fracture, Chicken Alfredo With Broccoli, Twelve Angry Men Summary, Corazoncito Google Translate, Lakeland Manatrigger, Yvonne Chaka Chaka Net Worth, Jimmy Carr Netflix 2020, Sheriff Meaning In Usa, Voltage Gain,

Subscribe to our blog