Several studies verify the close connection between prognosis and thymidine kinase activity in myelomas. The TK1 levels in fetal tissues during development are higher than those of the corresponding tissues later. We report on … The oldest commercially available technique uses iodo-deoxyuridine (idoxuridine) wherein a methyl group in thymidine has been replaced with radioactive iodine. Molecular Weight 366.17 (anhydrous basis) Beilstein/REAXYS Number 4086927 . Structure of Escherichia coli UMP kinase differs from that of other nucleoside monophosphate kinases and sheds new light on enzyme regulation. [117], Tumor markers may be used for the following purposes, Serum thymidine kinase 1 in different malignancies, "The use of serum deoxythymidine kinase as a prognostic marker, and in the monitoring of patients with non-Hodgkin's lymphoma", "The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene", "Mapping of the thymidine kinase genes of type 1 and type 2 herpes simplex viruses using intertypic recombinants", "Location and cloning of the herpes simplex virus type 2 thymidine kinase gene", "Mapping of the varicella zoster virus deoxypyrimidine kinase gene and preliminary identification of its transcript", "Identification of an Epstein-Barr virus-coded thymidine kinase", "Cell cycle-dependent regulation of thymidine kinase activity introduced into mouse LMTK- cells by DNA and chromatin-mediated gene transfer", "Control of thymidine kinase mRNA during the cell cycle", "Evidence for transcriptional and post-transcriptional control of the cellular thymidine kinase gene", "Cell cycle regulation of thymidine kinase: residues near the carboxyl terminus are essential for the specific degradation of the enzyme at mitosis", "Structures of thymidine kinase 1 of human and mycoplasmic origin", "Optimized assay for thymidine kinase and its application to the detection of antibodies against herpes simplex virus type 1- and 2-induced thymidine kinase", "Breast and prostate cancer patients differ significantly in their serum Thymidine kinase 1 (TK1) specific activities compared with those hematological malignancies and blood donors: implications of using serum TK1 as a biomarker", "A clinical evaluation of the TK 210 ELISA in sera from breast cancer patients demonstrates high sensitivity and specificity in all stages of disease", "Microchip immunoaffinity electrophoresis of antibody-thymidine kinase 1 complex", "Deoxythymidine kinase in the tumor cells and serum of patients with non-Hodgkin lymphomas", 10.1002/1097-0142(19841201)54:11<2450::aid-cncr2820541123>3.0.co;2-r, "Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia", "Clinical significance of thymidine kinase in Egyptian children with acute lymphoblastic leukemia", 10.1002/1097-0142(19860701)58:1<111::aid-cncr2820580120>3.0.co;2-k, 10.1002/1097-0142(19900815)66:4<722::aid-cncr2820660421>3.0.co;2-j, "Serum thymidine kinase 1 levels predict cancer-free survival following neoadjuvant, surgical and adjuvant treatment of patients with locally advanced breast cancer", "Elevated thymidine kinase 1 in serum following neoadjuvant chemotherapy predicts poor outcome for patients with locally advanced breast cancer", "Serum thymidine kinase 1 activity in solid tumor (breast and colorectal cancer) patients treated with adjuvant chemotherapy", 10.1002/(SICI)1097-0045(199607)29:1<15::AID-PROS2>3.0.CO;2-H, "Changes in serum thymidine kinase 1 levels during chemotherapy correlate with objective response in patients with advanced gastric cancer", "Serum thymidine kinase 1 levels correlate with clinical characteristics of esophageal squamous cell carcinoma", "Evaluation of the diagnostic value of alpha-l-fucosidase, alpha-fetoprotein and thymidine kinase 1 with ROC and logistic regression for hepatocellular carcinoma", "Protein expression of BIRC5, TK1, and TOP2A in malignant peripheral nerve sheath tumours--A prognostic test after surgical resection", "Rapid diagnosis of varicella-zoster virus infection by detection of viral deoxythymidine kinase in serum and vesicle fluid", "Properties of cellular and serum forms of thymidine kinase 1 (TK1) in dogs with acute lymphocytic leukemia (ALL) and canine mammary tumors (CMTs): implications for TK1 as a proliferation biomarker", "Serum thymidine kinase 1 and C-reactive protein as biomarkers for screening clinically healthy dogs for occult disease", "A New Sandwich ELISA for Quantification of Thymidine Kinase 1 Protein Levels in Sera from Dogs with Different Malignancies Can Aid in Disease Management", "Thymidine kinase 1 upregulation is an early event in breast tumor formation", 10.1002/1097-0142(19801101)46:9<2047::aid-cncr2820460924>3.0.co;2-q, 10.1002/1097-0142(197107)28:1<38::aid-cncr2820280108>3.0.co;2-w, 10.1002/1097-0142(19820201)49:3<460::aid-cncr2820490312>3.0.co;2-y, 10.1002/1097-0142(19850401)55:7<1530::aid-cncr2820550720>3.0.co;2-v, "The Memorial Sloan Kettering Cancer Center Recommendations for Prostate Cancer Screening", "Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta-analysis", "The history and future of targeting cyclin-dependent kinases in cancer therapy", UTP—glucose-1-phosphate uridylyltransferase, Galactose-1-phosphate uridylyltransferase, CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase, CDP-diacylglycerol—serine O-phosphatidyltransferase, CDP-diacylglycerol—inositol 3-phosphatidyltransferase, CDP-diacylglycerol—choline O-phosphatidyltransferase, N-acetylglucosamine-1-phosphate transferase, serine/threonine-specific protein kinases, https://en.wikipedia.org/w/index.php?title=Thymidine_kinase_in_clinical_chemistry&oldid=958864184, Creative Commons Attribution-ShareAlike License, This page was last edited on 26 May 2020, at 02:32. [10][11] J Biol Chem.

Soon it was shown that TK1 is present in the cytoplasm only in anticipation of cell division (cell cycle-dependent)[8][9] whereas the presence of TK2, which is located in the mitochondria, is cell cycle-independent. 2003 Mar 11;42(9):2568-77. doi: 10.1021/bi027302t. Synthesis and evaluation of 6-aza-2'-deoxyuridine monophosphate analogs as inhibitors of thymidylate synthases, and as substrates or inhibitors of thymidine monophosphate kinase in Mycobacterium tuberculosis.
Epub 2008 May 27. A microtiter ELISA based on monoclonal antibodies directed against the “210” epitope is available from AroCell.

The former was first found in fetal tissue, the second was found to be more abundant in adult tissue, and so initially they were termed fetal and adult thymidine kinases. This disease has a wide range of aggressivity, from slow-growing indolent disease that hardly requires treatment to highly aggressive, rapidly growing forms that should be treated urgently. This enzyme is intimately involved in activating nucleoside-based drugs directed against viral infections such as HIV and against certain types of cancers. Later, more sensitive, non-radioactive techniques enabled the lower increases from solid tumors to be measured accurately. Synthesis and inhibitory activity of thymidine analogues targeting Mycobacterium tuberculosis thymidine monophosphate kinase. However, no standard method for the extraction or for the assay has been developed and TK determination in extracts from cells and tissues have not been validated in relation to any specific clinical question, see however Arnér et al. Thymidine (deoxythymidine; other names deoxyribosylthymine, thymine deoxyriboside) is a pyrimidine deoxynucleoside.Deoxythymidine is the DNA nucleoside T, which pairs with deoxyadenosine (A) in double-stranded DNA. Whereas PSA is considered to give an indication of the tumor mass, thymidine kinase activity indicates the rate of proliferation and the markers thus supplement each other.[85][86][87][88]. After decantation and washing the radioactivity of the aluminum oxide gives a measure of the amount of thymidine kinase in the sample. The malignant cells are often not available for microscopic analysis, and the prognosis is often uncertain.


TK1 is synthesized by the cell during the S phase of cell division. [3] Somewhat later, it was shown that this incorporation was preceded by phosphorylation[4] and around 1960, the enzyme responsible was purified and characterized. The increases seen in both TK1 activity and concentration are greater in hematologic malignancies compared with solid tumors. Copyright © 2011 Elsevier Ltd. All rights reserved. AZTMP is measured in an immunoassay with anti-AZTMP antibodies and AZTMP-labeled peroxidase.  | 

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